Very rare (less than 0.01%): Movement disorder, ataxia, dizziness, seizure, anterograde amnesiaįrequency not reported: Involuntary movements, hyperactivity, decreased alertness, somnolence, prolonged/postoperative sedation, convulsions/drug withdrawal convulsions, feeling faint, tonic/clonic movements and muscle tremor Postmarketing reports: Acid taste, excessive salivation, retching, toothache Nervous systemĬommon (1% to 10%): Sedation/prolonged sedation, somnolence, depressed levels of consciousnessįrequency not reported: Drooling, dizziness, ataxia, vertigo, dysarthria, loss of balanceĬommon (1% to 10%): Headache, oversedation, drowsiness, seizure-like activity Very rare (less than 0.01%): Constipation, dry mouth Very common (10% or more): Emesis/vomiting (up to 11%)įrequency not reported: Gagging, salivation Respiratory adverse events included hypoxia, laryngospasm, rhonchi, coughing, respiratory depression, airway obstruction, upper airway congestion, and shallow respirations these side effects occurred more frequently at higher doses.ĭecreased tidal volume/respiratory rate occurred in 23.3% of patients given IV formulations and in 10.8% of patients given IM formulations.Īpnea occurred in 15.4% of patients given IV formulations. Postmarketing reports: Bronchospasm, hyperventilation, wheezing, shallow respirations, airway obstruction, tachypnea, dysphonia, yawning, continued phonation Very rare (less than 0.01%): Dyspnea, hiccup, laryngospasm, respiratory arrestįrequency not reported: Respiratory depression Very common (10% or more): Decreased tidal volume/respiratory rate (up to 23.3%), apnea (up to 15.4%)Ĭommon (1% to 10%): Hiccoughs, coughing, desaturation Uncommon (0.1% to 1%): Sneezing/rhinorrheaįrequency not reported: Apnea, hypercarbia, desaturation, stridor, hiccough Very common (10% or more): Respiratory adverse events (up to 11%)Ĭommon (1% to 10%): Respiratory depression, hypoxia, laryngospasm, upper airway obstruction, rhonchi, congestion Decreased tidal volume/respiratory rate and apnea were most commonly reported with parenteral formulations. The most commonly reported side effects with oral formulations include emesis and nausea.
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